1. Brad Williams and Jane Kerkovich-Williams
   Yorkie and Kelly Booth
2. Meredith Grey and Derek Shepherd
   Sookie St. James and Jackson Belleville

Meredith Grey and Derek Shepherd — played by Ellen Pompeo and Patrick Dempsey — made up the powerhouse couple on "Grey's Anatomy," a popular Shonda Rhimes series that premiered on ABC in 2005. The show follows the staff at a Seattle hospital.

1. Leslie Knope and Ben Wyatt
   Jackie Burkhart and Michael Kelso
2. Tony and Carmela Soprano
   AC Slater and Jessie Spano

"The Sopranos" premiered on HBO in 1999. The popular series starred the late James Gandolfini as Tony Soprano and Edie Falco as his wife, Carmela. The series ended in 2007.

1. Michael Cordero Jr. and Jane Villanueva
   Homer and Marge Simpson
2. Frank and Carol Lambert
   Scott McCall and Allison Argent

Marge and Homer and Marge Simpson head up the household on "The Simpsons," one of the most popular and longest-running shows in television history. The show premiered on FOX in 1989 and is still airing new episodes to date.

1. Buffy Summers and Angel
   Jay Pritchett and Gloria Delgado-Pritchett
2. Bailey Salinger and Sarah Reeves
   Marshall Eriksen and Lily Aldrin

"Buffy the Vampire Slayer" was the 1996 hit TV show that premiered years after the film. It starred Sarah Michelle Gellar as the title character, as well as David Boreanaz as Angel.

1. Philip and Vivian Banks
   Kurt Hummel and Blaine Anderson
2. James "Sawyer" Ford and Juliet Burke
   The Doctor and Rose Tyler

"The Fresh Prince of Bel-Air" premiered on NBC in 1990. It starred Will Smith as a teen sent to live with his aunt and uncle after getting into trouble on the rough streets of Philadelphia. James Avery played Philip Banks while Janet Hubert and Daphne Maxwell Reid split the role of Vivian.

1. Wilma and Fred Flintstone
   Jay and Michael Kyle
2. Carrie and Doug Heffernan
   D.J. Tanner and Steve Hale

Starring Leah Remini and Kevin James as Carrie and Doug Heffernan, "The King of Queens" documented their lives in Queens, New York. The series premiered on CBS in 1998 and ended in 2007.

1. Buffy Summers and Angel
   Magnus Bane and Alec Lightwood
2. Carrie Bradshaw and Mr. Big
   Monica Geller and Chandler Bing

Carrie Bradshaw and Mr. Big were characters from "Sex and the City." Starring Sarah Jessica Parker and Chris Noth, the series premiered on HBO in 1998 and ended in 2004. It later spawned two movies by the same name.

1. Angela Chase and Jordan Catalano
   Ross Gellar and Rachel Green
2. Becky Conner and Mark Healy
   Jughead Jones and Betty Cooper

Ross and Rachel were THE couple on "Friends," which premiered on NBC in 1994. The series followed six friends trying to figure out their personal and professional lives while living in the big city. The show made household names of actors David Schwimmer and Jennifer Aniston.

1. Jeannie and Major Anthony Nelson
   Florida and James Evans
2. Lorelai Gilmore and Luke Danes
   Cliff and Claire Huxtable

"Gilmore Girls" premiered on The WB in 2000. The series followed mother-daughter duo Lorelai and Rory Gilmore. Lauren Graham starred as Lorelai, while Scott Patterson played her love interest, Luke.

1. Eric Forman and Donna Pinciotti
   Mitchell Pritchett and Cameron Tucker
2. Steve Urkel and Laura Winslow
   Sheldon Cooper and Amy Fowler

Mitch and Cam, played by Jesse Tyler Ferguson and Eric Stonestreet, are fathers to Lily on the hit show "Modern Family." The sitcom first aired on ABC in 2009 and is still running.

1. Joanie Cunningham and Chachi Arcola
   Will Smith and Lisa Wilkes
2. Jason and Maggie Seaver
   Doug Ross and Carol Hathaway

Doug Ross and Carol Hathaway, played by actors George Clooney and Julianna Margulies, were characters on "ER." The show, about the staff at a Chicago County hospital, premiered in 1994. It went off the air in 2009.

1. Jane Villanueva and Michael Cordero Jr.
   Blaine Anderson and Kurt Hummel
2. Cliff and Claire Huxtable
   Fran Fine and Maxwell Sheffield

Fran Fine and Maxwell Sheffield, played by Fran Drescher and Charles Shaughnessy, were characters on the popular sitcom "The Nanny." The series ran for six seasons, from 1993 to 1999.

1. Paris Geller and Doyle McMaster
   Lucas Scott and Peyton Sawyer
2. Felicity Porter and Noel Crane
   Jessica Jones and Luke Cage

"One Tree Hill" starred Chad Michael Murray and Hilarie Burton as Lucas Scott and Peyton Sawyer. The series premiered on The WB in 2003 before ending its nine-year run in 2012 on The CW.

1. Captain Hook and Emma Swan
   Marissa Cooper and Alex Kelly
2. Jude Foster and Connor Stevens
   Zack Morris and Kelly Kapowski

"Saved by the Bell" premiered in 1989, starring Mark-Paul Gosselaar as cool kid Zack Morris. Tiffani-Amber Thiessen played his love interest, Kelly Kapowski, a cheerleader. They were Bayside High's most popular couple.

1. Ray and Debra Barone
   David Addison Jr. and Maddie Hayes
2. Dan and Roseanne Conner
   George and Jane Jetson

"Moonlighting" was the ABC show that starred Bruce Willis and Cybill Shepherd as David Addison Jr. and Maddie Hayes, two private detectives and complete opposites who eventually fall in love. The series ran for five seasons, from 1985 to 1989.

1. Tim and Jill Taylor
   Piper Chapman and Alex Vause
2. Bonnie Bennett and Enzo St. John
   Sam Malone and Diane Chambers

Bar owner Sam Malone and waitress Diane Chambers were each other's love interest in the early seasons of "Cheers," a series that ran from 1982 to 1993. Ted Danson and Shelley Long played the roles of Sam and Diane, respectively.

1. Bob and Linda Belcher
   Jack Shephard and Kate Austen
2. Preston Burke and Cristina Yang
   Miranda Hobbes and Steve Brady

"Lost" was a show about a group of people who survived a plane crash. Matthew Fox and Evangeline Lilly starred as Jack Shephard and Kate Austen. The series ran from 2004 to 2010 on ABC.

1. Rainbow and Dre Johnson
   Jim Halpert and Pam Beesly
2. Phil and Claire Dunphy
   Al and Peggy Bundy

Jim and Pam are characters from the NBC sitcom "The Office," which ran for nine seasons, starting in 2005. Played by John Krasinski and Jenna Fischer, the characters are employees of Dunder Mifflin Paper Company, Inc.

1. Brittany S. Pierce and Santana Lopez
   Chuck Bass and Blair Waldorf
2. Darrin and Samantha Stephens
   Blossom Russo and Vinnie Bonitardi

"Gossip Girl" first premiered on The CW in 2007. The series followed a group of well-to-do teens living in New York City. The characters included Blair, played by Leighton Meester, and Chuck, played by Ed Westwick.

1. Caleb Rivers and Hanna Marin
   Kevin Arnold and Winnie Cooper
2. Hank and Peggy Hill
   Dan Humphrey and Serena van der Woodsen

Kevin Arnold and Winnie Cooper, played by Fred Savage and Danica McKellar, were the stars of "The Wonder Years," which ran from 1988 to 1993. The series documented the on-and-off relationship of these two kids who had been friends since childhood.

1. Mike and Carol Brady
   Eric and Tami Taylor
2. Tony Micelli and Angela Bower
   Lois Lane and Clark Kent

"Friday Night Lights" was a show which followed a football coach and his players in a small town. Kyle Chandler starred as Coach Eric Taylor, while Connie Britton played his wife, Tami. The series was based on a novel by H. G. Bissinger.

1. Archie and Edith Bunker
   Penny and Leonard Hofstadter
2. Bob and Linda Belcher
   Jonah Simms and Amy Sosa

"All in the Family" starred Carroll O'Connor and Jean Stapleton as Archie and Edith Bunker. The series ran from 1971 to 1979 and sparked numerous spin-offs, including "Maude," "The Jeffersons" and "Good Times."

1. Rory Gilmore and Jess Mariano
   Brenda Walsh and Dylan McKay
2. Sun-Hwa and Jin-Soo Kwon
   Pacey Witter and Joey Potter

Pacey and Joey, played by actors Joshua Jackson and Katie Holmes, were main characters on "Dawson's Creek." The series premiered on The WB in 1998 and ran for six seasons. It was Holmes' big Hollywood break.

1. Ralph and Alice Kramden
   Lucious and Cookie Lyon
2. Cece Parekh and Schmidt
   Glenn Rhee and Maggie Greene

"The Honeymooners" starred Jackie Gleason and Audrey Meadows as Ralph and Alice Kramden. The show premiered in 1955. Though it only lasted one season, the series was extremely popular.

1. Adam and Kristina Braverman
   Seth Cohen and Summer Roberts
2. Jessica and Louis Huang
   Lucy and Ricky Ricardo

"I Love Lucy" starred real-life couple Lucille Ball and Desi Arnaz as the hilarious Lucy Ricardo and her husband, Ricky, a bandleader in New York City. The series premiered in 1951 on CBS and lasted six seasons.

1. Willow Rosenberg and Tara Maclay
   Lady Mary and Matthew Crawley
2. Andy Dwyer and April Ludgate
   Dwight Schrute and Angela Martin

Andy and April, played by Chris Pratt and Aubrey Plaza, were two characters on "Parks and Recreation." The series ran on NBC from 2009 until 2015. It starred Amy Poehler as a parks director in Pawnee, Ind.

1. Iris West and Barry Allen
   Olivia Pope and Fitzgerald Grant
2. Harriette and Carl Winslow
   Donna Paulsen and Harvey Specter

Written by Shonda Rhimes, "Scandal" starred Kerry Washington as Olivia Pope, a fixer and mistress to Fitzgerald Grant, the president of the United States. That role was played by Tony Goldwyn. The series ran from 2012 to 2018 on ABC.

1. Harry Goldenblatt and Charlotte York
   Rob Norris and Sharon Morris
2. Schmidt and Cece Parekh
   Martin Payne and Gina Waters-Payne

"Martin" was a show about a budding radio host and his friends. Martin Lawrence and Tisha Campbell-Martin starred as Martin and Gina. The series ran on Fox for five seasons, from 1992 to 1997.

1. Alice Pieszecki and Tasha Williams
   Ryan Booth and Alex Parrish
2. Nick Miller and Jessica Day
   David Silver and Donna Martin

"Beverly Hills 90210" was the popular 1990 Fox series about a group of teens growing up in Southern California. Brian Austin Green and Tori Spelling starred as couple David and Donna.

1. Connor Walsh and Oliver Hampton
   Carol and Mike Brady
2. Florida Evans and James Evans Sr.
   Melinda Gordon and Jim Clancy

"Good Times" told the story of Florida and James, a couple living in the projects with their children. It starred Esther Rolle and John Amos. The show first aired in 1974 on CBS and ran for six seasons.

1. Cory Matthews and Topanga Lawrence
   Eric Forman and Donna Pinciotti
2. Donna Martin and David Silver
   Fox Mulder and Dana Scully

"Boy Meets World" was a popular sitcom that starred Ben Savage and Danielle Fishel as Cory Matthews and Topanga Lawrence. In grade school, Cory, a class clown, would tease nerdy Topanga, but the two started seeing each other differently as they matured. The series aired on ABC from 1993 to 2000.

1. Charlotte York and Harry Goldenblatt
   Seth Cohen and Summer Roberts
2. Ryan Atwood and Marissa Cooper
   Paul and Jamie Buchman

"Mad About You" starred Paul Reiser and Helen Hunt as Paul and Jamie Buchman, a newly wedded couple living in New York City. The show ran on NBC for seven seasons, from 1992 to 1999.

1. Kevin and Jenny MacArthur
   Glenn Rhee and Maggie Greene
2. Jesse and Becky Katsopolis
   David Healy and Darlene Conner

"Full House" was a sitcom about a widowed father raising his three daughters with the help of Uncle Jesse (played by John Stamos), Aunt Becky (played by Lori Loughlin) and a friend. The show ran from 1987 to 1995 on ABC.

1. Randall and Beth Pearson
   George and Louise Jefferson
2. Lois Lane and Clark Kent
   Stef and Lena Foster

"The Jeffersons" told the story of George and Louise Jefferson, who moved to the Upper East Side after their dry-cleaning business started becoming a success. A spin-off of "All in the Family," the series ran for 11 seasons, starting in 1975.

1. Sabrina Spellman and Harvey Kinkle
   Nathan and Haley Scott
2. Mindy Lahiri and Danny Castellano
   Elena Gilbert and Damon Salvatore

"The Mindy Project" starred Mindy Kaling and Chris Messina as Mindy and Danny. The series premiered on Fox in 2012 before moving to Hulu in 2015. The series ended in 2017 after six seasons.