Do You Remember Who Played These "Friends" Guest Roles?

When Jessica Lockheart is killed off of "Days of Our Lives," Joey's comatose character, Dr. Drake Ramoray, receives her brain via a transplant surgery only a soap opera could come up with.

In the season two episode, "The One With the Chicken Pox," Ryan and Phoebe reunite for a romantic two-week rendez-vous. Unfortunately, both have chickenpox and are itching wildly the entire time.

As Melissa Warburton, Rachel "Ray-Ray" Green's old sorority sister, Winona Ryder shares a kiss with Jennifer Aniston in this much talked-about episode, "The One With Rachel's Big Kiss."

This double-length episode aired right after Super Bowl XXX in 1996. Along with "The One Hundredth" and "The Last One," it's one of the few episode titles that does not reference an aspect of the show's plot.

In "The One Where the Stripper Cries," Monica and Rachel are surprised to learn that Phoebe wants a stripper at her bridal shower, so they hire the first person they find in the phonebook. Reportedly, DeVito came up with the stripper's hilarious dance routine himself.

Baldwin appeared as Parker in two-episode from this season - "The One With the Tea Leaves" and "The One in Massapequa." Reportedly, the character was based on a real-life boyfriend of one of the show's creators.

Willis won an Emmy for Outstanding Guest Actor in a Comedy Series for his role as Paul Stevens. The character, who despises Ross and briefly dates Rachel, appears in three episodes of the show.

Penn appeared as Eric in two-episode from season eight - "The One with the Halloween Party" and "The One with the Stain." While Eric attempts to date Phoebe after learning Ursula lied to him, the fact that she looks just like her sister makes it too weird.

Witherspoon appeared as Rachel's spoiled younger sister in "The One with Rachel's Sister" and "The One Where Chandler Can't Cry." Witherspoon and Aniston teamed up again, 19 years later, to star in the hit Apple+ show, "The Morning Show."

Applegate appeared in the season nine episode, "The One with Rachel's Other Sister," and the season 10 episode, "The One Where Rachel's Sister Babysits." Applegate won an Emmy Award for Outstanding Guest Actress in a Comedy Series for her first appearance as Amy.

This episode from season 10, called "The One with Ross' Tan," is also well-known for its hilarious subplot, which features Ross attempting to get a spray tan but failing miserably.

In "The One with Two Parts, Part 2," Clooney and Wylie play a pair of doctors who go on a double date with Monica and Rachel. At the time this episode aired (1995), "ER" was one of NBC's most popular shows.

Rudd appeared as Mike in 17 episodes of the last two seasons of "Friends." He's introduced in the season 9 episode, "The One with the Pediatrician," and is featured for the last time in the show's finale, "The Last One."

"The One with Ross's Wedding" was the season finale of the show's fourth season. In the episode, Rachel flies to London to tell Ross, who is about to marry Emily, that she still loves him.

Ross is horrified when he discovers that Rachel's date, Tommy, has a terrible temper and screams at people when she's not there. Eight years after this episode aired, Ben Stiller and Jennifer Aniston went on to star in the hit 2004 rom-com, "Along Came Polly."

Faris appeared in four episodes of season 10, including the series finale, "The Last One." Fun fact: David Schwimmer directed the first episode featuring Faris, called "The One with the Birth Mother."

Shields played Erika Ford, a crazy fan who thought Dr. Drake Ramoray, Joey's soap opera character, was a real person. This happened in the extra-long episode, "The One After the Superbowl," which also featured Julia Roberts's famous guest appearance.

In "The One Where Rosita Dies," Phoebe takes a job as a telemarketer, which is how she meets the unhappy office manager Earl. The show's subplot involves the death of Rosita, Joey's favorite chair.

Freddie Prinze Jr. is the son of Freddie Prinze, an actor and stand-up comedian who was popular in the 1970s. Tragically, he died in 1977 when Freddie Prinze Jr. was less than a year old.

When Chandler has to spend the holidays in Tulsa because of work, Monica becomes jealous of his attractive new co-worker, Wendy. She's especially worried when she learns Wendy was a former Miss Oklahoma runner-up.

Goldblum starred in two of the highest-grossing films of the '90s - "Jurassic Park" and "Independence Day" - as well as indie hits such as "Igby Goes Down" and "The Grand Budapest Hotel."

Ross finds himself in a bind in "The One with Ross's Grant" when he learns that the professor administering the grant he's up for, Dr. Benjamin Hobart, is an ex-boyfriend of his current girlfriend, Charlie.

Jon Lovitz is best known as a member of the "Saturday Night Live" cast from 1985 to 1990. He made a second appearance on "Friends" as the stoned restaurant-owner Steve in the season nine episode, "The One with the Blind Dates."

Elle Macpherson appeared as Joey's new roommate and love interest Janine Lecroix in five episodes of "Friends." The character was introduced in the episode "The One Where Phoebe Runs" and made her last appearance in "The One with the Apothecary Table."

Richard Burke was Monica's boyfriend during season two. The pair had a brief reunion in season three before breaking up for good. Selleck made his final appearance as Richard in season six, when he tried to get in the way of Chandler's marriage proposal.

All the guys lust over Cassie Gellar in this season seven episode, including cousin Ross. Richards was widely regarded as a sex symbol in the late '90s and early '00s thanks to her roles in movies like "Wild Things."

In "The One with the Dirty Girl," Romijn plays Cheryl, a beautiful woman with an incredibly messy apartment. Ross tries to ignore the mess but is forced to leave when he discovers a rat running around the apartment.

Thomas appeared as Sandra Greene three times total - twice in season two and once in season eight. In her final appearance, "The One with the Baby Shower," she announces her plan to move in with Rachel to help her take care of her new baby.

"Pyramid" was a revamped version of the popular 1970s game show, "The $10,000 Pyramid," which has had many iterations over the years. The version hosted by Donny Osmond aired from 2002 to 2004.

Frye plays Katie, one of Joey's dates in this episode from season five. She's spunky, energetic, and unfortunately for Joey, freakishly strong. Every time she playfully punches him in the arm, it hurts.

When this episode of "Friends" aired in November of 2000, "Sex and the City" had been on the air for two years. The hit HBO show ran until 2004 and was followed by two successful movies.

In "The One with the Baby on the Bus," Hynde played Stephanie Schiffer, a singer and guitarist hired to perform at Central Perk, much to Phoebe's dismay. The episode's title refers to the subplot in which Joey and Chandler accidentally leave baby Ben on a New York City bus.

In "The One with the Jam," Arquette plays Malcolm, a young man who starts stalking Phoebe, believing she is Ursula. Arquette and Courteney Cox married in 1999. The couple, who also starred together in the "Scream" movies, split in 2013.

In "The One After the Superbowl," which features several celebrity guests, Monica and Rachel meet Jean-Claude Van Damme on the set of the movie he is filming on location in New York City.