Lisa Kudrow plays therapist Fiona Wallace in "Web Therapy," which was later picked up by Showtime.

After a long struggle with addiction, Matthew Perry wanted to give back by opening up his Malibu mansion to former addicts struggling to live healthier lives.

Jennifer Aniston became a star of the big screen after "Friends," taking the lead role in many movies. While she starred in "Marley and Me" and "We're the Millers," it was Amy Adams who played the lead in "Leap Year."

Schwimmer starred as O.J.'s famous attorney in the 2016 drama.

Matt LeBlanc starred in the spinoff "Joey," which ran from 2004 to 2006 and followed his struggles in the acting world.

After splitting with hubby Brad Pitt in 2005, Aniston waited 10 years before tying the knot again to actor Justin Theroux in 2015.

Cox played tough reporter Gale Weathers in the 1996 slasher flick.

Cox met David Arquette — who played Officer Dewey Riley — on the set of "Scream."

Schwimmer voiced the character Melman the giraffe in "Madagascar."

Gwyneth Paltrow played opposite David Schwimmer in the 1996 rom-com.

LeBlanc played Jason Gibbons, an action star and Alex's boyfriend, in the 2000 remake of the classic TV show.

Matthew Perry played White House lawyer Joe Quincy in Seasons 4 and 5 of the show.

Aniston's character, a waitress at a restaurant called Chotchkie's, was constantly in trouble at work for not wearing enough pieces of flair.

LeBlanc plays a fictionalized version of himself in the Showtime series, which first aired in 2011.

LeBlanc stars as Coach Lyman in "Pucks!," an Americanized version of a popular British show that is nothing like its poor creators imagined it would be.

Perry plays the easy-going Oscar Madison in the CBS series, which premiered in 2015.

Courtney Cox plays Jules Cobb, a recent divorcee raising her children while trying to navigate the dating world.

Kudrow plays Valerie Cherish on the sitcom, which first aired in 2005 before being cancelled, then brought back in 2014.

"I'm It!" made Cherish a star, but her celebrity quickly faded once the show went off the air. In "The Comeback," Lisa Kudrow plays Cherish as she tries to make it big once more.

Zac Efron plays a 17-year old version of Matthew Perry's character in the 2009 film.

Schwimmer turned down the role of Agent J — which went to Will Smith instead — in order to star in "The Pallbearer."

Cox and former husband David Arquette named their daughter Coco.

Matthew Perry got plenty of buzz when he pitched the show — about a foul-mouthed talk show host — to Showtime, but the network ultimately decided to pass.

Aniston plays a sexually-charged dentist in the 2011 film.

David Schwimmer played the evil Captain Herbert Sobel — who led his men to disaster on the battlefield — in the HBO series.

Aniston earned a Golden Globes nod for "Cake," in which she plays a patient suffering from chronic pain.

Kudrow plays idealistic Montana congresswomen Josie Marcus in "Scandal."

In 2014, Cox announced her engagement to Snow Patrol band member Johnny McDaid. The pair split in 2015.

Kudrow plays college dean Carol Gladstone in the 2014 flick.

LeBlanc became the first non-Brit chosen to host "Top Gear" in 2015.