1. osteoporosis
   Rocky Mountain fever
2. stone man syndrome

Stone man syndrome is a rare genetic disease that causes connective tissue and muscle to be slowly turned into bone. The disease is not only terrifying, but it's painful, too.

1. The bone growth accelerates.
   The rest of the body is damaged.
2. The patient is cured.

Like something out of a horror movie, removing the unwanted bone material just causes the disease to spread faster. There is no cure for this disease.

1. brain
   skin
2. circulatory system

Morgellons is considered a type of delusional parasitosis, in which patients feel a stinging sensation and believe (incorrectly) that they have red, blue or black fibers emerging from their skin.

1. saliva
   urine
2. water

If you're suffering from aquagenic uticaria, you're allergic to water. When you come into contact with water, you develop hives.

1. about 30
   about 300
2. about 3,000

Aquagenic uticaria is an extremely rare genetic disease that affects only about 30 people worldwide. Because the disease is so rare, there's no real treatment for it.

1. The ventricles clog.
   The muscle fibers degenerate.
2. sharp changes in blood pressure

Baroreflex failure causes sudden changes in blood pressure, often as a reaction to pain or stress. The cause is often unknown, but surgery or stress may play a role.

1. skin
   liver
2. hair

Adams-Oliver syndrome manifests itself in different ways, but patients often have missing skin, or missing or deformed limbs. It's caused by genetic mutations.

1. They can't absorb certain nutrients.
   Their eyes don't develop.
2. They can't breathe properly.

Babies with abetalipoproteinemia have a hard time absorbing nutrients like fats, vitamins and cholesterol. Unless treated, it can cascade into all sorts of developmental problems.

1. Screaming Death
   Laughing Death
2. Shaking Death

A first symptom of Kuru is abrupt laughing fits. Months later, the laughing death would cause people to lose their bodily functions and then die.

1. cannibalism
   toxic waste
2. genetic mutations

The disease was discovered in New Guinea in the 1950s -- the outbreak came to a halt once the practice of cannibalism was ended.

1. They abruptly understand one foreign language.
   They suddenly can't understand their native language.
2. They begin speaking in an unrecognizable dialect.

In this bizarre phenomenon, people suddenly begin speaking with a foreign accent. First thought to be a mental disorder, it's actually caused by a brain malformation.

1. 60
   6
2. 2

The first case was recorded in 1941. Since then, only about 60 cases of foreign accent syndrome have been recorded.

1. blue skin disorder
   Bright's disease
2. the Devil's Eye

People with methemoglobinemia, or blue skin disease, have elevated levels of methemoglobin in their blood, causing a bluish tinge to their skin.

1. Ohio
   California
2. Kentucky

The Blue Fugates was the nickname for the Fugate family from Kentucky, which intermarried and thus perpetuated the genetic mutation that caused blue skin disease.

1. Ausems Wittebol-Post Hennekam syndrome
   progeria
2. Alpers syndrome

In progeria, young people look very old. The affected rarely live past the age of 13.

1. about 150
   about 15
2. about 5

There are about 150 confirmed cases and researchers suspect there may be more patients that haven't been identified. The disease is caused by a genetic mutation.

1. spontaneous bleeding
   sudden muscle weakness
2. uncontrollable vomiting

Guillain–Barré syndrome causes abrupt muscle weakness due to nervous system damage. It affects only about one or two people per 100,000 annually.

1. deafness
   blindness
2. albinism

Blindness isn't a symptom, but deafness and albinism are signs of ABCD syndrome. If patients are diagnosed early, those with ABCD syndrome can live fairly healthy lives.

1. fish skin disease
   fish head disease
2. fish tail disease

Ichthyosis vulgaris is fish skin disease, in which the body can't shed dead skin cells, leading to thick patches of scaly skin. Most cases are minor, but there is no cure.

1. continuous headaches
   painful muscle spasms
2. blindness

Fields' disease is a progressive muscle disorder and sufferers may experience more than 100 painful muscle spasms each day.

1. 2
   20
2. 200

Only two people in history are known to have had Fields' disease -- identical twins Kirstie and Catharine Fields, from South Wales.

1. huge skull
   excessive hair growth
2. oversized limbs

Hypertrichosis (sometimes nicknamed werewolf syndrome) results in excessive hair growth, sometimes all over the body. Some sufferers have been paraded in freak shows.

1. Fewer than 200
   Fewer than 2000
2. Fewer than 100000

Fewer than 200 people have been diagnosed with werewolf syndrome. Some people have so much hair that it grows even on the palms of their hands.

1. open sore syndrome
   black tar syndrome
2. tree man syndrome

Epidermodysplasia verruciformis is called tree man syndrome. It's a very rare disorder in which the skin uncontrollably develops tree-like growths, usually on the feet and hands.

1. toddler age
   adolescent age
2. about age 30

As toddlers with ataxia telangiectasia try to walk, they sway and fall in a manner similar to intoxicated people. It's a genetic disease that causes serious disabilities.

1. face
   hands
2. abdomen

People with Moebius syndrome have trouble with muscle control in their faces and eyes. They often can't frown or smile, or even raise their eyebrows.

1. perhaps 1 in 50,000
   perhaps 1 in 5 million
2. perhaps 1 in 500 million

Researchers aren't sure, but about 1 in 50,000 to 1 in 500,000 babies are born with Moebius syndrome. The disease is sometimes called congenital facial diplegia or Moebius spectrum, among other things.

1. oversized nose
   oversized feet
2. oversized head

Bannayan–Riley–Ruvalcaba syndrome children have oversized heads. It's a rare genetic disease that causes physical and mental disorders.

1. green
   red
2. purple

Gene mutations cause porphyria, a genetic disorder affecting the development of red blood cells. Sufferers often have symptoms like pain, insomnia … or purple urine and feces.

1. 1
   5
2. 29

RPI deficiency is called the rarest disease in the world, having affected only one known person, diagnosed in 1999. It affects the white matter of the brain and is diagnosed via MRI.